Zhang Q, Zhao YZ, Ma HH, Wang D, Cui L, Li WJ, Wei A, Wang CJ, Wang TY, Li ZG, Zhang R. A study of ruxolitinib response-based stratified treatment for pediatric hemophagocytic lymphohistiocytosis. Blood. 2022 Jun 16;139(24):3493-3504. doi: 10.1182/blood.2021014860. PMID: 35344583.

Bi X, Zhang Q, Chen L, Liu D, Li Y, Zhao X, Zhang Y, Zhang L, Liu J, Wu C, Li Z, Zhao Y, Ma H, Huang G, Liu X, Wang QF, Zhang R. NBAS, a gene involved in cytotoxic degranulation, is recurrently mutated in pediatric hemophagocytic lymphohistiocytosis. J Hematol Oncol. 2022 Jul 28;15(1):101. doi: 10.1186/s13045-022-01318-z. PMID: 35902954; PMCID: PMC9331571.

Huang K, Chen Z, Wu R. "A personalized limited sampling approach to better estimate terminal half-life of FVIII concentrates": Comment from Huang et al. J Thromb Haemost. 2022 Oct;20(10):2444-2445. doi: 10.1111/jth.15833. PMID: 36123571.

Huang K, Wang Y, Zhen Y, Li G, Wu X, Zhang N, Chen Z, Wu R. Inter-individual variability in pharmacokinetics and clinical features in pediatric patients with severe hemophilia A. Thromb Res. 2022 May;213:71-77. doi: 10.1016/j.thromres.2022.03.008. Epub 2022 Mar 12. PMID: 35305529.

Yao JF, Wang D, Ma HH, Lian HY, Zhang L, Wang TY, Li ZG, Jiang J, Cui L, Zhang R. Characteristics and Treatment Outcomes of Pediatric Langerhans Cell Histiocytosis with Thymic Involvement. J Pediatr. 2022 May;244:194-202.e5. doi: 10.1016/j.jpeds.2022.01.007. Epub 2022 Jan 19. PMID: 35065150.

Sun J, Li Z, Li G, Huang K, Ai D, Liu G, Yao W, Xie X, Gu H, Zhen Y, Chen Z, Wu R. Low-dose immune tolerance induction in children with severe hemophilia A with high-titer inhibitors: Type of factor 8 mutation and outcomes. Res Pract Thromb Haemost. 2022 Oct 26;6(7):e12824. doi: 10.1002/rth2.12824. PMID: 36313984; PMCID: PMC9606347.

Sun J, Li Z, Huang K, Ai D, Li G, Xie X, Gu H, Liu G, Zhen Y, Chen Z, Wu R. F8 gene mutation spectrum in severe hemophilia A with inhibitors: A large cohort data analysis from a single center in China. Res Pract Thromb Haemost. 2022 Jun 8;6(4):e12723. doi: 10.1002/rth2.12723. PMID: 35702590; PMCID: PMC9175357.

Huang K, Zhen Y, Li G, Wu X, Chen Z, Wu R. Enhanced pharmacokinetics and reduced bleeds in boys with hemophilia A after switching to Kovaltry from other standard half-life factor VIII concentrates. Res Pract Thromb Haemost. 2022 Mar 25;6(2):e12686. doi: 10.1002/rth2.12686. PMID: 35356665; PMCID: PMC8956787.

Yue ZX, Xing TY, Zhao W, Zhao Q, Wang XS, Su Y, Gao C, Liu SG, Ma XL. MYCN amplification plus 1p36 loss of heterozygosity predicts ultra high risk in bone marrow metastatic neuroblastoma. Cancer Med. 2022 Apr;11(8):1837-1849. doi: 10.1002/cam4.4583. Epub 2022 Feb 9. PMID: 35137546; PMCID: PMC9041068.

Wang D, Chen XH, Wei A, Zhou CJ, Zhang X, Ma HH, Lian HY, Zhang L, Zhang Q, Huang XT, Wang CJ, Yang Y, Liu W, Wang TY, Li ZG, Cui L, Zhang R. Clinical features and treatment outcomes of pediatric Langerhans cell histiocytosis with macrophage activation syndrome-hemophagocytic lymphohistiocytosis. Orphanet J Rare Dis. 2022 Apr 4;17(1):151. doi: 10.1186/s13023-022-02276-y. PMID: 35379272; PMCID: PMC8981711.

Huang K, Ai D, Li G, Zhen Y, Wang Y, Zhang N, Huo A, Liu G, Chen Z, Wu R. Individualised prophylaxis based on personalised target trough FVIII level optimised clinical outcomes in paediatric patients with severe haemophilia A. Haemophilia. 2022 Nov;28(6):e209-e218. doi: 10.1111/hae.14635. Epub 2022 Jul 18. PMID: 35850182; PMCID: PMC9796890.

Zhao XX, Lian HY, Zhang L, Ma HH, Wang D, Zhao YZ, Liu W, Chen XH, Wang TY, Li ZG, Zhang R. Significance of serum Th1/Th2 cytokine levels in underlying disease classification of childhood HLH. Cytokine. 2022 Jan;149:155729. doi: 10.1016/j.cyto.2021.155729. Epub 2021 Oct 19. PMID: 34673333.

Yang Y, Wang C, Wang D, Cui L, Li N, Lian H, Ma H, Zhao Y, Zhang L, Liu W, Wang Y, Wu W, Zhang R, Li Z, Wang T. Clinical study of MAP2K1-mutated Langerhans cell histiocytosis in children. J Cancer Res Clin Oncol. 2022 Sep;148(9):2517-2527. doi: 10.1007/s00432-021-03810-4. Epub 2021 Sep 30. PMID: 34595543.

Lian H, Cui L, Yang Y, Wei A, Cheng H, Li N, Zhang L, Ma H, Zhao X, Wang T, Li Z, Zhang R. Second-line regimen for CNS-involved pediatric Langerhans cell histiocytosis. Pituitary. 2022 Feb;25(1):108-115. doi: 10.1007/s11102-021-01176-x. Epub 2021 Jul 24. PMID: 34302575.

Liu G, Huang K, Li G, Zhen Y, Li Z, Chen Z, Wu R. Real-world experience of emicizumab prophylaxis in young children with hemophilia A: retrospective data from China. Front Pediatr. 2022 Oct 19;10:992267. doi: 10.3389/fped.2022.992267. PMID: 36340724; PMCID: PMC9627604.

Gu H, Chen Z, Ma J, Ma J, Fu L, Zhang R, Wang T, Wu R. Case report: Effectiveness of sirolimus in a de novo FAS mutation leading to autoimmune lymphoproliferative syndrome-FAS and elevated DNT/Treg ratio. Front Pediatr. 2022 Jul 28;10:868193. doi: 10.3389/fped.2022.868193. PMID: 35967554; PMCID: PMC9366043.

Ai D, Huang K, Li G, Zhen Y, Wu X, Zhang N, Huo A, Chen Z, Wu R. Exploration of the minimum necessary FVIII level at different physical activity levels in pediatric patients with hemophilia A. Front Pediatr. 2022 Nov 1;10:1045070. doi: 10.3389/fped.2022.1045070. PMID: 36389359; PMCID: PMC9665406.

Yuan Y, Li J, Xue TL, Hu HR, Lin W, Liu SG, Zhang RD, Zheng HY, Gao C. Prognostic significance of NOTCH1/FBXW7 mutations in pediatric T cell acute lymphoblastic leukemia: a study of minimal residual disease risk-directed CCLG-ALL 2008 treatment protocol. Leuk Lymphoma. 2022 Jul;63(7):1624-1633. doi: 10.1080/10428194.2022.2032033. Epub 2022 Feb 6. PMID: 35129045.

Yang FF, Xue TL, Gao C, Wu Y, Lin W, Li J, Zhang RD, Zheng HY, Liu SG. Effects of SLCO1B1 on elimination and toxicities of high-dose methotrexate in pediatric acute lymphoblastic leukemia. Pharmacogenomics. 2022 Oct;23(15):821-834. doi: 10.2217/pgs-2022-0098. Epub 2022 Oct 4. PMID: 36193736.

Wang CJ, Jia MZ, Deng LP, Li WJ, Zhang Q, Zhang TJ, Li SY, Cui L, Li ZG. Interaction between CASP8AP2 and ZEB2-CtBP2 Regulates the Expression of LEF1. Pediatr Hematol Oncol. 2022 Sep;39(6):549-560. doi: 10.1080/08880018.2022.2033369. Epub 2022 Feb 10. PMID: 35139734.

Fan H, Xing T, Hong H, Duan C, Zhao W, Zhao Q, Wang X, Huang C, Zhu S, Jin M, Su Y, Gao C, Ma X. The expression of PHOX2B in bone marrow and peripheral blood predicts adverse clinical outcome in non-high-risk neuroblastoma. Pediatr Hematol Oncol. 2022 May;39(4):343-356. doi: 10.1080/08880018.2021.1995090. Epub 2021 Nov 9. PMID: 34752187.

Shi H#, He H#, Cui #L, Kvedaraite E#, Bian Z#, Huang T#, Lee C, Li ZG, He J, Gong Y, Li Z, Zhou J, Zeng Y, Li X, Ni Y, Bai Z, Liu C, Li N, Ma H, Wang D, Lan Y, Ginhoux F*, Zhang R*, Liu B*. Transcriptomic Landscape of Circulating Mononuclear Phagocytes in Langerhans Cell Histiocytosis at Single-cell Level. Blood. 2021, blood.2020009064. doi: 10.1182/blood.2020009064. Online ahead of print.

Wang CJ, Cui L, Ma HH, Wang D, Zhang L, Lian HY, Li WJ, Zhang Q, Wang TY*, Li ZG*, Zhang R*. BRAFV600E mutation in cell-free DNA, rather than in lesion tissues, at diagnosis is an independent prognostic factor in children with Langerhans cell histiocytosis. Molecular Cancer Therapeutics, 2021, 20(7):1316-1323.

Cui L, Gao C, Wang CJ, Zhao XX, Li WJ, Li ZG, Zheng HY, Wang TY, Zhang RD*. Combined analysis of IKZF1 deletions and CRLF2 expression on prognostic impact in pediatric B-cell precursor acute lymphoblastic leukemia. Leukemia and Lymphoma, 2021,62(2):410-418.

Zhang Q#, Wei A#, Ma HH, Zhang L, Lian HY, Wang D, Zhao YZ, Cui L, Li WJ, Yang Y, Wang TY, Li ZG*, Zhang R*. A pilot study of ruxolitinib as a front-line therapy for 12 children with secondary hemophagocytic lymphohistiocytosis. Haematologica, 2021,106(7):1892-1901.

Yang Y, Wang D, Cui L, Ma HH, Zhang L, Lian HY, Zhang Q, Zhao XX, Zhang LP, Zhao YZ, Li N, Wang TY, Li ZG*, Zhang R*. Effectiveness and safety of Dabrafenib in the treatment of 20 Chinese children with BRAFV600E-mutated Langerhans cell histiocytosis. Cancer Research and Treatment, 2021,53(1):261-269.

Lian H, Wei A, He L, Yang Y, Ma H, Zhang L, Guan Y, Zhang Q, Wang D, Li Z*, Zhang R*, Wang T*. Clinical analysis of pediatric systemic juvenile xanthogranulomas: a retrospective single-center study. Frontiers in Pediatrics, 2021,9:672547.

Ma H#, Zhang L#, Wei A#, Yang J, Wang D, Zhang Q, Zhao Y, Chen S, Lian H, Zhang L, Zhou C, Qin M, Li Z*, Wang T*, Zhang R*. Outcome of L-DEP regimen for treatment of pediatric chronic active Epstein-Barr virus infection. Orphanet Journal of Rare Diseases, 2021,16(1):269.

Chen S#, Wei A#, Ma H, Zhang L, Lian H, Zhao Y, Zhang Q, Cheng F, Wang D, Wang T, Li Z*, Zhang R*. Clinical features and prognostic factors of children with chronic active Epstein-Barr virus infection: a retrospective analysis of a single center. J Pediatr, 2021,S0022-3476(21)00674-0.

Cui L, Zhang L, Ma HH, Wang CJ, Wang D, Lian HY, Li WJ, Zhang Q, Li N, Wang TY*, Li ZG*, Zhang R*. Circulating cell-free BRAF V600E during chemotherapy is associated with prognosis of children with Langerhans cell histiocytosis. Haematologica, 2020,105(9):e444-447.

Cui L, Gao C, Wang CJ, Liu SG, Wu MY, Zhang RD*, Li ZG*. Low expression of CTBP2 and CASP8AP2 predicts risk of relapse in childhood B-cell precursor acute lymphoblastic leukemia: a retrospective cohort study. Pediatr Hematol Oncol. 2020;37(8):732-746.

Gao C; Liu SG; WT; Yue ZX; Zhao XX; Xing TY; Chen ZP; Zheng HY*; Li ZG*. Down regulation of CREBBP inhibits proliferation and cell cycle progression and induces daunorubicin resistance in leukemia cells. Molecular Medicine Reports. 2020, 22(4): 2905-2915.

Gao C#; Liu SG#; Yue ZX; Liu Y; Liang J; Li J; Zhang YY; Yu JL; Wu Y; Lin W; Zheng HY; Zhang RD*. Clinical-biological characteristics and treatment outcomes of pediatric pro-B ALL patients enrolled in BCH-2003 and CCLG-2008 protocol: A study of 121 Chinese children. Cancer Cell International. 2019, 19: 293.

Zhang Q, Ma HH , Ma J, Wang D, Zhao YZ , Wang TY, Li ZG, Wu RH, Zhang R*. Clinical and genetic analysis of immunodeficiency-related diseases associated with PIK3CD mutations. Pediatr Invest, 2018, 2(4): 257-262.

Cui L#, Li ZG#, Chai YH#, Yu J#, Gao J#, Zhu XF#, Jin RM#, Shi XD#, Zhang LP#, Gao YJ#, Zhang RD, Zheng HY, Hu SY, Cui YH, Zhu YP, Zou Y, Ng MHL, Xiao Y, Li JH, Zhang YH, He HL, Xian Y, Wang TY*, Li CK*, Wu MY*; Chinese Children Leukemia Group(CCLG). Am J Hematol, 2018, 93(7): 913-920.

Liu FF#, Wang KL#, Deng LP, Liu X, Wu MY, Wang TY, Cui L*, Li ZG*. CASP8AP2 transcription and enhances sensitivity to chemotherapeutic drugs in acute lymphoblastic leukemia. Cancer Cell Int, 2018, 18: 40.

Xu Y#, Cui L#, Dibello A, Wang L, Lee J, Saidi L, Lee JG, Ye Y*. DNAJC5 facilitates USP19-dependent unconventional secretion of misfolded cytosolic proteins. Cell Discov, 2018, 4:11.

Wang D#, Cui L#, Li ZG, Zhang L, Lian HY, Ma HH, Zhao YZ, Zhao XX, Wang TY, Zhang R*. Clinical Research of Pulmonary Langerhans Cell Histiocytosis in Children. Chinese Medical Journal. 2018, 131(15): 1793-8.

Zhao YZ#, Zhang Q#, Li ZG, Zhang L, Lian HY, Ma HH, Wang D, Zhao XX, Wang TY, Zhang R1*. Central Nervous System Involvement in 179 Chinese Children with Hemophagocytic Lymphohistiocytosis. Chinese Medical Journal. Chinese Medical Journal. 2018, 131(15): 1786-92.

Gao C; Zhang RD; Liu SG; Zhao XX; Cui L; Yue ZX; Li WJ; Chen ZP; Li ZG; Rao Q; Wang M; Zheng HY*; Wang JX*. Low CREBBP expression is associated with adverse long-term outcomes in paediatric acute lymphoblastic leukaemia. Eurpean Journal of Haematology. 2017, 99(2): 150-159.