北京儿童医院

感染与病毒研究室
2025-03-17 14:26:02
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Duan Y, Zhu Y, Zhang L, Wang W, Zhang M, Tian J, Li Q, Ai J, Wang R, Xie Z. Activation of the NLRP3 inflammasome by human adenovirus type 7 L4 100-kilodalton protein. Front Immunol. 2024 Apr 17;15:1294898. doi: 10.3389/fimmu.2024.1294898. PMID: 38660301; PMCID: PMC11041921.

Fu Y, Li F, Zhu Y, Huang L, Li Q, Zhang H, Zhong L, Zhang H, Luo ZX, Lu G, Deng J, Cao L, Wu Y, Jin R, Li L, Xu L, Chen X, Xie Z. A multi-center study on genetic variations in the fusion protein of respiratory syncytial virus from children with Acute Lower Respiratory Tract Infections in China during 2017-2021. Virol Sin. 2024 Oct;39(5):727-736. doi: 10.1016/j.virs.2024.09.002. Epub 2024 Sep 13. PMID: 39265703; PMCID: PMC11738779.

Zhu Y, Sun Y, Li C, Lu G, Jin R, Xu B, Shang Y, Ai J, Wang R, Duan Y, Chen X, Xie Z. Genetic characteristics of human parainfluenza viruses 1-4 associated with acute lower respiratory tract infection in Chinese children, during 2015-2021. Microbiol Spectr. 2024 Oct 3;12(10):e0343223. doi: 10.1128/spectrum.03432-23. Epub 2024 Sep 12. PMID: 39264196; PMCID: PMC11448424.

Zhang XL, Zhang X, Hua W, Xie ZD, Liu HM, Zhang HL, Chen BQ, Chen Y, Sun X, Xu Y, Shu SN, Zhao SY, Shang YX, Cao L, Jia YH, Lin LN, Li J, Hao CL, Dong XY, Lin DJ, Xu HM, Zhao DY, Zeng M, Chen ZM, Huang LS. Expert consensus on the diagnosis, treatment, and prevention of respiratory syncytial virus infections in children. World J Pediatr. 2024 Jan;20(1):11-25. doi: 10.1007/s12519-023-00777-9. Epub 2023 Dec 8. Erratum in: World J Pediatr. 2024 Feb 25. doi: 10.1007/s12519-023-00792-w. PMID: 38064012; PMCID: PMC10828005.

Wang J, Feng Q, Duan Y, Ai J, Zhu Y, Wang R, Chen X, Lu G, Sun Y, Li C, Jin R, Shang Y, Xu B, Xie Z. Human adenovirus type 4 (HAdV-4) associated acute respiratory tract infection in children & genetic characteristics of HAdV-4 in China: a prospective multicenter study. BMC Infect Dis. 2024 Sep 9;24(1):936. doi: 10.1186/s12879-024-09835-7. PMID: 39251906; PMCID: PMC11385803.

Dilmurat D, Wang X, Gao L, Tian J, Ai J, Zhang L, Liu M, Feng G, Zeng Y, Wang R, Xie Z. Clinical epidemiology of Epstein-Barr virus-associated Lymphoproliferative Disorders (EBV-LPDs) in hospitalized children: A six-year multi-institutional study in China. Ital J Pediatr. 2024 Jul 2;50(1):125. doi: 10.1186/s13052-024-01685-y. PMID: 38956696; PMCID: PMC11218373.

Ai J, Xiao H, Zhang L, Ma H, Wang D, Dilmurat D, Wang R, Xie Z. Dysfunction of γδ T cells in pediatric chronic active Epstein-Barr virus infection. Ital J Pediatr. 2024 Oct 12;50(1):213. doi: 10.1186/s13052-024-01783-x. PMID: 39396033; PMCID: PMC11470581.

Chen G, Zhang L, Wang R, Xie Z. Histone methylation in Epstein-Barr virus-associated diseases. Epigenomics. 2024;16(11-12):865-877. doi: 10.1080/17501911.2024.2345040. Epub 2024 May 10. PMID: 38869454; PMCID: PMC11370928.

Chen X, Wang F, Fu Y, Huang L, Li F, Zhao H, Guan X, Li Q, Li Q, Wang Y, Guo Y, Xie Z. Development and evaluation of a multiplex digital PCR method for sensitive and accurate detection of respiratory pathogens in children. Virology. 2024 Feb;590:109948. doi: 10.1016/j.virol.2023.109948. Epub 2023 Nov 29. PMID: 38064870.

Li F, Zhu Y, Li Q, Guan X, Zhang H, Li C, Zhang M, Li L, Fu Y, Duan Y, Huang L, Xie Z, Chen X. Genomic characteristics of human respiratory syncytial virus from children in China during 2017-2020. Arch Virol. 2024 Oct 10;169(11):219. doi: 10.1007/s00705-024-06138-9. PMID: 39387930.

Tian J, Wang X, Li Q, Zhang L, Ai J, Feng G, Zeng Y, Wang R, Xie Z. Clinical epidemiology of adenovirus pneumonia among Chinese hospitalized children. Arch Microbiol. 2024 Mar 4;206(4):135. doi: 10.1007/s00203-024-03870-3. PMID: 38436806.

Li F, Guo L, Li Q, Xu H, Fu Y, Huang L, Feng G, Liu G, Chen X, Xie Z. Changes in the epidemiology and clinical characteristics of viral gastroenteritis among hospitalized children in the Mainland of China: a retrospective study from 2016 to 2020. BMC Pediatr. 2024 May 4;24(1):303. doi: 10.1186/s12887-024-04776-1. PMID: 38704530; PMCID: PMC11069194.

李飞,安淑华,郭佳运,. 20142016年河北省石家庄地区儿童重症社区获得性肺炎的病原学分析[J]. 中华实验和临床病毒学杂志,2024,38(5):513-520.

黄陆慈,邵魏,郭凌云,. 20162021年我国儿童病毒性心肌炎流行特征及疾病负担分析[J]. 中华实验和临床病毒学杂志,2024,38(4):432-438.

王金津,段亚丽,艾军红,. 2017-2020年我国儿童急性下呼吸道人腺病毒感染流行病学特征分析[J]. 中国预防医学杂志,2024,25(3):283-288.

迪拉热·迪力木拉提,艾军红,田娇,. ddPCR在儿童异基因造血干细胞移植后EB病毒感染监测中的初步应用[J]. 中华实验和临床病毒学杂志,2024,38(3):331-336.

李飞,陈祥鹏. 肠道病毒检测技术的临床应用与建议[J]. 中国临床医生杂志,2024,52(7):765-768.

刘梦佳, 王然, & 谢正德. 传染性单核细胞增多症的流行病学,免疫机制及临床管理. 中国科学:生命科学,2024,54(12): 2311-2320.

艾军红, 王然, & 谢正德. 慢性活动性EB病毒感染的发病机制和诊治进展. 中国科学:生命科学,2024,54(12): 2321-2329.

冯黔玉,谢正德. 线粒体自噬在病毒感染中的研究进展[J]. 病毒学报,2024,40(5):1111-1120.

中华预防医学会. 我国婴幼儿呼吸道合胞病毒感染被动免疫预防专家共识[J]. 中华预防医学杂志,2024,58(12):1853-1865.

Tian J, Wang XY, Zhang LL, Liu MJ, Ai JH, Feng GS, Zeng YP, Wang R, Xie ZD. Clinical epidemiology and disease burden of bronchiolitis in hospitalized children in China: a national cross-sectional study. World J Pediatr. 2023 Sep;19(9):851-863. doi: 10.1007/s12519-023-00688-9. Epub 2023 Feb 16. PMID: 36795317; PMCID: PMC9933022.

Jiang RM, Xie ZD, Jiang Y, Lu XX, Jin RM, Zheng YJ, Shang YX, Xu BP, Liu ZS, Lu G, Deng JK, Liu GH, Wang XC, Wang JS, Feng LZ, Liu W, Zheng Y, Shu SN, Lu M, Luo WJ, Liu M, Cui YX, Ye LP, Shen AD, Liu G, Gao LW, Xiong LJ, Bai Y, Lin LK, Wei Z, Xue FX, Wang TY, Zhao DC, Shao JB, Ng DK, Wong GW, Zhao ZY, Li XW, Yang YH, Shen KL. Diagnosis, treatment and prevention of severe acute respiratory syndrome coronavirus 2 infection in children: experts' consensus statement updated for the Omicron variant. World J Pediatr. 2024 Mar;20(3):272-286. doi: 10.1007/s12519-023-00745-3. Epub 2023 Sep 7. PMID: 37676610.

Zhang L, Duan Y, Wang W, Li Q, Tian J, Zhu Y, Wang R, Xie Z. Autophagy induced by human adenovirus B7 structural protein VI inhibits viral replication. Virol Sin. 2023 Oct;38(5):709-722. doi: 10.1016/j.virs.2023.08.002. Epub 2023 Aug 5. PMID: 37549881; PMCID: PMC10590704.

Han S, Xu B, Feng Q, Feng Z, Zhu Y, Ai J, Deng L, Li C, Cao L, Sun Y, Fu Z, Jin R, Shang Y, Chen Z, Xu L, Xie Z, Shen K. Multicenter analysis of epidemiological and clinical features of pediatric acute lower respiratory tract infections associated with common human coronaviruses in China, 2014-2019. Virol J. 2023 Oct 10;20(1):229. doi: 10.1186/s12985-023-02198-6. PMID: 37817170; PMCID: PMC10566024.

Chen X, Wang H, Li Q, Qi Y, Li F, He W, Wang Q, Jin F, Guo Y, Hei M, Xie Z. A fatal case of neonatal viral sepsis caused by human parainfluenza virus type 3. Virol J. 2023 Oct 27;20(1):248. doi: 10.1186/s12985-023-02141-9. PMID: 37891594; PMCID: PMC10612315.

Li Q, Wang R, Xu H, Zhang L, Fu Y, Tian J, Liu M, Feng G, Zeng Y, Chen X, Xie Z. Epidemiology and Disease Burden of Hospitalized Children With Viral Central Nervous System Infections in China, 2016 to 2020. Pediatr Neurol. 2023 Jan;138:38-44. doi: 10.1016/j.pediatrneurol.2022.09.003. Epub 2022 Oct 14. PMID: 36356470.

Wang R, Xie Z. The responsibility of thwarting and managing Japanese encephalitis cannot be understated-Outbreaks or resurgences may manifest, catching us off guard. PLoS Negl Trop Dis. 2023 Nov 2;17(11):e0011698. doi: 10.1371/journal.pntd.0011698. PMID: 37917595; PMCID: PMC10621813.

Feng Q, Feng Z, Yang B, Han S, Wen S, Lu G, Jin R, Xu B, Zhang H, Xu L, Xie Z. Metatranscriptome Reveals Specific Immune and Microbial Signatures of Respiratory Syncytial Virus Infection in Children. Microbiol Spectr. 2023 Mar 2;11(2):e0410722. doi: 10.1128/spectrum.04107-22. Epub ahead of print. PMID: 36861979; PMCID: PMC10100699.

Zhen Z, Zhang L, Li Q, Zhu Y, Wang X, Fu X, Ai J, Wang R, Xie Z, Ma S. Cross-reactive antibodies against monkeypox virus exist in the population immunized with vaccinia Tian Tan strain in China. Infect Genet Evol. 2023 Sep;113:105477. doi: 10.1016/j.meegid.2023.105477. Epub 2023 Jun 29. PMID: 37392823.

Liu M, Wang R, Xie Z. T cell-mediated immunity during Epstein-Barr virus infections in children. Infect Genet Evol. 2023 Aug;112:105443. doi: 10.1016/j.meegid.2023.105443. Epub 2023 May 16. PMID: 37201619.

Li Q, Chen X, Ai J, Li L, Li C, Zhu Y, Wang R, Duan Y, Zhang M, Xie Z. Clinical and molecular epidemiologic features of enterovirus D68 infection in children with acute lower respiratory tract infection in China. Arch Virol. 2023 Jul 15;168(8):206. doi: 10.1007/s00705-023-05823-5. PMID: 37453955.

Feng Z, Xu B, Zhong L, Chen J, Deng J, Luo Z, Cao L, Tang Y, Li C, Jin R, Deng L, Shang Y, Wu Y, Zhao H, Feng Q, Chen X, Xu L, Xie Z. A multicentre study on the incidence of respiratory viruses in children with community-acquired pneumonia requiring hospitalization in the setting of the zero-COVID policy in China. Arch Virol. 2023 Jan 13;168(2):64. doi: 10.1007/s00705-023-05698-6. PMID: 36639581; PMCID: PMC9839207.

Ge H, Zhang L, Liu M, Yang X, Wu X, Wang R, Xie Z. Standardization of Transfer across Labs between Flow Cytometers for Detection of Lymphocytes in Japanese Encephalitis Vaccinated Children. J Vis Exp. 2023 Feb 10;(192). doi: 10.3791/64949. PMID: 36847400.

Tian J, Wang X, Zhang L, Li Q, Feng G, Zeng Y, Wang R, Xie Z. Clinical epidemiology and disease burden of adenoviral encephalitis in hospitalized children in China: A nationwide cross-sectional study. Pediatr Investig. 2023 Aug 25;7(4):247-253. doi: 10.1002/ped4.12396. PMID: 38050533; PMCID: PMC10693664.

中国初级卫生保健基金会病原检测专业委员会,中国医疗保健国际交流促进会分子诊断学分会,中国研究型医院学会神经科学专委会脑炎协作组. 病毒性脑(膜)炎病原体诊断技术应用专家共识[J]. 中华医学杂志,2023,103(9):648-657.

朱云,谢正德. 重视呼吸道人副流感病毒感染[J]. 中华实验和临床病毒学杂志,2023,37(5):469-471.

付艺亮,徐会,李奇,. 20162020年我国儿童疱疹性咽峡炎住院病例流行特征及疾病负担分析[J]. 中华实验和临床病毒学杂志,2023,37(1):7-12.

蔡士奇,徐保平,李昌崇,. 20142020年儿童社区获得性肺炎中人副流感病毒感染的多中心研究[J]. 中华实验和临床病毒学杂志,2023,37(5):472-479.

蒋荣猛,谢正德,姜毅,. 儿童新型冠状病毒感染诊断、治疗和预防专家共识(第五版)[J]. 中华实用儿科临床杂志,2023,38(1):20-30.

Jiang RM, Zheng YJ, Zhou L, Feng LZ, Ma L, Xu BP, Xu HM, Liu W, Xie ZD, Deng JK, Xiong LJ, Luo WJ, Liu ZS, Shu SN, Wang JS, Jiang Y, Shang YX, Liu M, Gao LW, Wei Z, Liu GH, Gang Liu, Xiang W, Cui YX, Lu G, Lu M, Lu XX, Jin RM, Bai Y, Ye LP, Zhao DC, Shen AD, Ma X, Lu QH, Xue FX, Shao JB, Wang TY, Zhao ZY, Li XW, Yang YH, Shen KL. Diagnosis, treatment, and prevention of monkeypox in children: an experts' consensus statement. World J Pediatr. 2022 Nov 21:1–12. doi: 10.1007/s12519-022-00624-3. Epub ahead of print. PMID: 36409451; PMCID: PMC9685019.

Yuan J, Feng Z, Wang Q, Han L, Guan S, Liu L, Ye H, Xu L, Han X. 3'UTR of SARS-CoV-2 spike gene hijack host miR-296 or miR-520h to disturb cell proliferation and cytokine signaling. Front Immunol. 2022 Sep 27;13:924667. doi: 10.3389/fimmu.2022.924667. PMID: 36238276; PMCID: PMC9552351.

Chen X, Qu X, Liu C, Zhang Y, Zhang G, Han P, Duan Y, Li Q, Wang L, Ruan W, Wang P, Wei W, Gao GF, Zhao X, Xie Z. Human FcRn Is a Two-in-One Attachment-Uncoating Receptor for Echovirus 18. mBio. 2022 Aug 30;13(4):e0116622. doi: 10.1128/mbio.01166-22. Epub 2022 Jul 5. PMID: 35862785; PMCID: PMC9426509.

Zhao H, Feng Q, Feng Z, Zhu Y, Ai J, Xu B, Deng L, Sun Y, Li C, Jin R, Shang Y, Chen X, Xu L, Xie Z. Clinical characteristics and molecular epidemiology of human metapneumovirus in children with acute lower respiratory tract infections in China, 2017 to 2019: A multicentre prospective observational study. Virol Sin. 2022 Dec;37(6):874-882. doi: 10.1016/j.virs.2022.08.007. Epub 2022 Aug 22. PMID: 36007839; PMCID: PMC9797368.

Liu M, Wang X, Zhang L, Feng G, Zeng Y, Wang R, Xie Z. Epidemiological characteristics and disease burden of infectious mononucleosis in hospitalized children in China: A nationwide retrospective study. Virol Sin. 2022 Oct;37(5):637-645. doi: 10.1016/j.virs.2022.07.007. Epub 2022 Jul 12. PMID: 35840103; PMCID: PMC9583177.

Feng Q, Lin S, Liu H, Yang B, Han L, Han X, Xu L, Xie Z. Meta-Analysis of Whole Blood Transcriptome Datasets Characterizes the Immune Response of Respiratory Syncytial Virus Infection in Children. Front Cell Infect Microbiol. 2022 Apr 13;12:878430. doi: 10.3389/fcimb.2022.878430. PMID: 35493728; PMCID: PMC9043598.

Zhao H, Xu W, Wang L, Zhu Y, Wang X, Liu Y, Ai J, Feng Q, Deng L, Sun Y, Li C, Jin R, Shang Y, Gao H, Qian S, Xu L, Xie Z. WU Polyomavirus Infection in Children With Acute Lower Respiratory Tract Infections in China, 2017 to 2019: Case Reports and Multicentre Epidemiological Survey. Front Cell Infect Microbiol. 2022 Mar 11;11:835946. doi: 10.3389/fcimb.2021.835946. PMID: 35360221; PMCID: PMC8963484.

Feng Z, Xu L, Xie Z. Receptors for Respiratory Syncytial Virus Infection and Host Factors Regulating the Life Cycle of Respiratory Syncytial Virus. Front Cell Infect Microbiol. 2022 Feb 25;12:858629. doi: 10.3389/fcimb.2022.858629. PMID: 35281439; PMCID: PMC8913501.

Liu J, Zhao H, Feng Z, Liu Y, Feng Q, Qian S, Xu L, Gao H, Xie Z. A severe case of human rhinovirus A45 with central nervous system involvement and viral sepsis. Virol J. 2022 Apr 22;19(1):72. doi: 10.1186/s12985-022-01799-x. PMID: 35459180; PMCID: PMC9034649.

Zhao H, Liu Y, Feng Z, Feng Q, Li K, Gao H, Qian S, Xu L, Xie Z. A fatal case of viral sepsis and encephalitis in a child caused by human adenovirus type 7 infection. Virol J. 2022 Sep 28;19(1):154. doi: 10.1186/s12985-022-01886-z. PMID: 36171632; PMCID: PMC9517974.

Zhang L, Wang R, Xie Z. The roles of DNA methylation on the promotor of the Epstein-Barr virus (EBV) gene and the genome in patients with EBV-associated diseases. Appl Microbiol Biotechnol. 2022 Jun;106(12):4413-4426. doi: 10.1007/s00253-022-12029-3. Epub 2022 Jun 28. Erratum in: Appl Microbiol Biotechnol. 2022 Nov;106(21):7373. PMID: 35763069; PMCID: PMC9259528.

Zhang L, Wang X, Liu M, Feng G, Zeng Y, Wang R, Xie Z. The epidemiology and disease burden of congenital TORCH infections among hospitalized children in China: A national cross-sectional study. PLoS Negl Trop Dis. 2022 Oct 14;16(10):e0010861. doi: 10.1371/journal.pntd.0010861. PMID: 36240247; PMCID: PMC9604879.

Wang R, Wang X, Zhang L, Feng G, Liu M, Zeng Y, Xie Z. The epidemiology and disease burden of children hospitalized for viral infections within the family Flaviviridae in China: A national cross-sectional study. PLoS Negl Trop Dis. 2022 Jul 5;16(7):e0010562. doi: 10.1371/journal.pntd.0010562. PMID: 35788743; PMCID: PMC9286261.

Zhang M, Chen X, Wang W, Li Q, Xie Z. Genetic characteristics of Coxsackievirus A6 from children with hand, foot and mouth disease in Beijing, China, 2017-2019. Infect Genet Evol. 2022 Dec;106:105378. doi: 10.1016/j.meegid.2022.105378. Epub 2022 Oct 17. PMID: 36257478.

Li Q, Wang R, Xu H, Zhang L, Fu Y, Tian J, Liu M, Feng G, Zeng Y, Chen X, Xie Z. Epidemiology and Disease Burden of Hospitalized Children With Viral Central Nervous System Infections in China, 2016 to 2020. Pediatr Neurol. 2023 Jan;138:38-44. doi: 10.1016/j.pediatrneurol.2022.09.003. Epub 2022 Oct 14. PMID: 36356470.

Wang R, Zhang M, Zhang L, Liu M, Shan C, An J, Xie Z. Japanese Encephalitis Vaccine Generates Cross-Reactive Memory T Cell Responses to Zika Virus in Humans. J Trop Med. 2022 Nov 19;2022:8379286. doi: 10.1155/2022/8379286. PMID: 36444358; PMCID: PMC9701130.

Chen X, Zhu Y, Li Q, Lu G, Li C, Jin R, Li L, Xu B, Gao L, Yin J, Xie Z. Genetic characteristics of human coronavirus HKU1 in mainland China during 2018. Arch Virol. 2022 Nov;167(11):2173-2180. doi: 10.1007/s00705-022-05541-4. Epub 2022 Jul 16. PMID: 35840864; PMCID: PMC9287133.

Zou X, Zhu Y, Li C, Duan Y, Zhang L, Guo X, Hou W, Xie Z, Lu Z. Construction of Adenoviral Vectors using DNA Assembly Technology. J Vis Exp. 2022 Jun 16;(184). doi: 10.3791/64033. PMID: 35786609.

Zhang L, Zhang M, Liu M, Ai J, Tian J, Ge H, Wang R, Xie Z. Detection of Polyfunctional T Cells in Children Vaccinated with Japanese Encephalitis Vaccine via the Flow Cytometry Technique. J Vis Exp. 2022 Sep 23;(187). doi: 10.3791/64671. PMID: 36149727.

Zhang L, Liu M, Zhang M, Ai J, Tian J, Wang R, Xie Z. Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis. J Vis Exp. 2022 Sep 7;(187). doi: 10.3791/64212. PMID: 36156539.

Wang R, Xie Z. Non-hepatotropic viral hepatitis and its causative pathogens: The ongoing need for monitoring in children with severe acute hepatitis of unknown etiology. Pediatr Investig. 2022 Aug 1;6(3):151-155. doi: 10.1002/ped4.12340. PMID: 36203520; PMCID: PMC9523801.

朱云,张林琳,段亚丽,.人腺病毒7DNA结合蛋白的原核表达及多克隆抗体制备[J].中华预防医学杂志, 2022, 56(2):7.

冯黔玉,杨丽娟,赵宏伟,.儿童社区获得性肺炎血清免疫学病毒特异性抗体检测与呼吸道病毒核酸检测结果一致性分析[J].中华实验和临床病毒学杂志, 2022, 36(2):5.

谢正德,邓继岿,任丽丽,. 儿童呼吸道感染病原体核酸检测专家共识[J]. 中华实用儿科临床杂志,2022,37(5):321-332.

王然,张林琳,田娇,. 病毒核酸检测技术及临床应用[J]. 中华实验和临床病毒学杂志,2022,36(3):337-345.

李奇,陈祥鹏,谢正德. 肠道病毒受体的研究进展[J]. 病毒学报,2022,38(5):1206-1213.

蒋荣猛,谢正德,姜毅,. 儿童新型冠状病毒感染诊断、治疗和预防专家共识(第四版)[J]. 中华实用儿科临床杂志,2022,37(14):1053-1065.

蒋荣猛,郑跃杰,周蕾,. 儿童猴痘诊疗和预防专家共识[J]. 中华实用儿科临床杂志,2022,37(13):964-973.

谢正德,郑跃杰,卢根,. 预防婴儿呼吸道合胞病毒感染的人源化单克隆抗体临床研究最新进展[J]. 中华实用儿科临床杂志,2022,37(7):481-485.

朱云,卢根,靳蓉,. 20172020年我国儿童急性下呼吸道感染住院病例中呼吸道合胞病毒的感染情况分析[J]. 中华预防医学杂志,2022,56(12):1739-1744.


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