北京儿童医院

血液疾病研究室
2025-03-17 14:33:30
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Ge J, Zhang Q, Ma H, Wang D, Zhao Y, Zhu T, Wang W, Zhou C, Wei A, Lian H, Qin M, Yang J, Li Z, Wang T, Zhang R. Ruxolitinib-based regimen in children with primary hemophagocytic lymphohistiocytosis. Haematologica. 2024 Feb 1;109(2):458-465. doi: 10.3324/haematol.2023.283478. PMID: 37470145; PMCID: PMC10828753.

Ma J, Cui C, Tang Y, Hu Y, Dong S, Zhang J, Xie X, Meng J, Wang Z, Zhang W, Chen Z, Wu R. Machine learning models developed and internally validated for predicting chronicity in pediatric immune thrombocytopenia. J Thromb Haemost. 2024 Apr;22(4):1167-1178. doi: 10.1016/j.jtha.2023.12.006. Epub 2023 Dec 15. PMID: 38103736.

Gu H, Wang Z, Xie X, Chen H, Ouyang J, Wu R, Chen Z. HIF-1α induced by hypoxic condition regulates Treg/Th17 axis polarization in chronic immune thrombocytopenia. Int Immunopharmacol. 2024 Apr 20;131:111810. doi: 10.1016/j.intimp.2024.111810. Epub 2024 Mar 15. PMID: 38492341.

Zhao C, Zhang Q, Zhang R, Lian H, Ma H, Zhao X, Li Z. Genetic and clinical characteristics of primary hemophagocytic lymphohistiocytosis in children. Ann Hematol. 2024 Jan;103(1):17-28. doi: 10.1007/s00277-023-05499-6. Epub 2023 Oct 18. PMID: 37851074.

Huang XT, Wang CJ, Gao C, Xue TL, Zhao ZJ, Wang TY, Wu MY, Cui L, Zhang RD, Li ZG. Relationship between subtype-specific minimal residual disease level and long-term prognosis in children with acute lymphoblastic leukemia. Ann Hematol. 2024 Sep;103(9):3657-3665. doi: 10.1007/s00277-024-05687-y. Epub 2024 Mar 18. PMID: 38494553.

Yang C, Li N, Zhang M, Huang S, Jin L, Liu SG, Zhou CJ, Li ZG, Duan YL. Inborn errors of immunity and its clinical significance in children with lymphoma in China: a single-center study. J Pediatr (Rio J). 2024 Jul-Aug;100(4):384-391. doi: 10.1016/j.jped.2024.02.002. Epub 2024 Mar 25. PMID: 38547930; PMCID: PMC11331237.

Xie X, Gu H, Ma J, Fu L, Ma J, Zhang J, Wu R, Chen Z. FOXO1 Single-Nucleotide Polymorphisms Are Associated with Bleeding Severity and Sensitivity of Glucocorticoid Treatment of Pediatric Immune Thrombocytopenia. DNA Cell Biol. 2024 Jun;43(6):279-287. doi: 10.1089/dna.2023.0431. Epub 2024 Apr 29. PMID: 38683649.

Zhu T, Wang CJ, Lian HY, Ma HH, Wang D, Wang TY, Zhang R, Cui L, Li ZG. The plasma-soluble CSF1R level is a promising prognostic indicator for pediatric Langerhans cell histiocytosis. Pediatr Blood Cancer. 2024 Jun;71(6):e30970. doi: 10.1002/pbc.30970. Epub 2024 Mar 31. PMID: 38556751.

Wang CJ, Zhu T, Zhao CZ, Cui H, Wang D, Zhao ZJ, Huang XT, Li HL, Liu FF, Zhang R, Li ZG, Cui L. BRAF-V600E mutations in plasma and peripheral blood mononuclear cells correlate with prognosis of pediatric Langerhans cell histiocytosis treated with first-line therapy. Pediatr Blood Cancer. 2024 Sep;71(9):e31099. doi: 10.1002/pbc.31099. Epub 2024 Jun 6. PMID: 38845144.

Zhen Y, Ai D, Huang K, Li G, Chen Z, Wu R. The influence of dead space in blood sampling needle on FVIII level and pharmacokinetic profiles in children with hemophilia. Hematology. 2024 Dec;29(1):2314871. doi: 10.1080/16078454.2024.2314871. Epub 2024 Feb 12. PMID: 38346146.

Chen H, Ma J, Ouyang J, Fu L, Ma J, Yao J, Wu R, Chen Z. The Differences of Serum Thrombopoietin Levels Between Acquired Aplastic Anemia and Immune Thrombocytopenia in Pediatric Patients. J Pediatr Hematol Oncol. 2024 Aug 1;46(6):281-286. doi: 10.1097/MPH.0000000000002873. Epub 2024 Jun 10. PMID: 38857156.

黄筱彤,史利欢,薛天琳,. IDE基因表达水平在急性淋巴细胞白血病患儿中的预后意义[J]. 中国循证儿科杂志,2024,19(4):281-286.

马宏浩,魏昂,张利平,. 克拉屈滨联合阿糖胞苷治疗儿童难治复发性朗格罕细胞组织细胞增生症疗效分析[J]. 中国小儿血液与肿瘤杂志,2024,29(3):159-165.

Cui L, Wang CJ, Lian HY, Zhang L, Ma HH, Wang D, Chen FF, Zhang Q, Yang Y, Wei A, Huang XT, Zhu T, Wang TY, Li ZG, Zhang R. Clinical outcomes and prognostic risk factors of Langerhans cell histiocytosis in children: Results from the BCH-LCH 2014 protocol study. Am J Hematol. 2023 Apr;98(4):598-607. doi: 10.1002/ajh.26829. Epub 2023 Jan 9. PMID: 36594188.

Liu S, Xiang Y, Wang B, Gao C, Chen Z, Xie S, Wu J, Liu Y, Zhao X, Yang C, Yue Z, Wang L, Wen X, Zhang R, Zhang F, Xu H, Zhai X, Zheng H, Zhang H, Qian M. USP1 promotes the aerobic glycolysis and progression of T-cell acute lymphoblastic leukemia via PLK1/LDHA axis. Blood Adv. 2023 Jul 11;7(13):3099-3112. doi: 10.1182/bloodadvances.2022008284. PMID: 36912760; PMCID: PMC10362547.

Ai D, Cui C, Tang Y, Wang Y, Zhang N, Zhang C, Zhen Y, Li G, Huang K, Liu G, Chen Z, Zhang W, Wu R. Machine learning model for predicting physical activity related bleeding risk in Chinese boys with haemophilia A. Thromb Res. 2023 Dec;232:43-53. doi: 10.1016/j.thromres.2023.10.012. Epub 2023 Oct 21. PMID: 37931538.

Sun J, Li Z, Li G, Liu G, Yao W, Zhen Y, Chen Z, Wu R. Early immune tolerance induction is a unique predictor of favorable outcomes in hemophilia A children with intron 22 inversion and high-responding inhibitors. Thromb Res. 2023 Jun;226:56-60. doi: 10.1016/j.thromres.2023.04.002. Epub 2023 Apr 11. PMID: 37121012.

Wang Z, Cheng X, Wang N, Meng J, Ma J, Chen Z, Wu R. Transient increase in platelet counts associated with COVID-19 infection during TPO-RA as the second-line treatment in children with ITP. Br J Haematol. 2023 Nov;203(3):384-388. doi: 10.1111/bjh.19040. Epub 2023 Aug 23. PMID: 37609794.

Zhang Q, Zhou CJ, Li DH, Cui L, Li WJ, Ma HH, Zhao YZ, Wang D, Li ZG, Wang TY, Wei L, Duan YL, Zhang R. Efficacy of ruxolitinib for HAVCR2 mutation-associated hemophagocytic lymphohistiocytosis and panniculitis manifestations in children. Br J Haematol. 2023 Jul;202(1):135-146. doi: 10.1111/bjh.18817. Epub 2023 Apr 16. PMID: 37062931.

Chen H, Xie X, Ma J, Fu L, Zhao X, Xing T, Gao C, Wu R, Chen Z. Elevated TCR-αβ+ double-negative T cells in pediatric patients with acquired aplastic anemia. Clin Chim Acta. 2023 Aug 1;548:117492. doi: 10.1016/j.cca.2023.117492. Epub 2023 Jul 19. PMID: 37479012.

Li W, Liu S, Wang C, Cui L, Zhao X, Liu W, Zhang R, Li Z. Correction to: DNMT3A low-expression is correlated to poor prognosis in childhood B-ALL and confers resistance to daunorubicin on leukemic cells. BMC Cancer. 2023 Apr 21;23(1):366. doi: 10.1186/s12885-023-10862-x. Erratum for: BMC Cancer. 2023 Mar 18;23(1):255. doi: 10.1186/s12885-023-10724-6. PMID: 37085757; PMCID: PMC10120268.

Ou W, Zhao Y, Wei A, Ma H, Zhang L, Lian H, Zhang Q, Chen S, Wang D, Li Z, Wang T, Zhang R. Chronic Active Epstein-Barr Virus Infection With Central Nervous System Involvement in Children: A Clinical Study of 22 Cases. Pediatr Infect Dis J. 2023 Jan 1;42(1):20-26. doi: 10.1097/INF.0000000000003738. Epub 2022 Oct 11. PMID: 36476521.

Ou W, Zhao Y, Wei A, Ma H, Zhang Q, Zhang L, Lian H, Wang D, Li Z, Wang T, Zhang R. Serum cytokine pattern in children with hemophagocytic lymphohistiocytosis. Ann Hematol. 2023 Apr;102(4):729-739. doi: 10.1007/s00277-023-05132-6. Epub 2023 Feb 16. PMID: 36792730; PMCID: PMC9931565.

Zou T, Wei A, Ma H, Lian H, Liu Y, Wang D, Zhao Y, Cui L, Li Z, Zhang R, Wang T. Systemic juvenile xanthogranuloma: A systematic review. Pediatr Blood Cancer. 2023 May;70(5):e30232. doi: 10.1002/pbc.30232. Epub 2023 Feb 13. PMID: 36779547.

Dong S, Gu H, Zhang J, Fu L, Xie X, Ma J, Ma J, Chen Z, Wu R. Anti-glycoprotein autoantibodies are related to bleeding severity in children with newly diagnosed ITP and very low platelet counts. Pediatr Blood Cancer. 2023 Feb;70(2):e30094. doi: 10.1002/pbc.30094. Epub 2022 Nov 15. PMID: 36377718.

Yue Z, Gao C, Xing T, Zhao W, Duan C, Wang X, Jin M, Su Y. Combined analysis of PHOX2B at two time points and its value for further risk stratification in high-risk neuroblastoma. Pediatr Blood Cancer. 2023 May;70(5):e30261. doi: 10.1002/pbc.30261. Epub 2023 Feb 23. PMID: 36815592.

Wang Y, Li J, Xue TL, Tian S, Yue ZX, Liu SG, Gao C. Clinical, biological, and outcome features of P2RY8-CRLF2 and CRLF2 over-expression in pediatric B-cell precursor acute lymphoblastic leukemia according to the CCLG-ALL 2008 and 2018 protocol. Eur J Haematol. 2023 Jun;110(6):669-679. doi: 10.1111/ejh.13948. Epub 2023 Mar 2. PMID: 36814093.

Li Z, Zhang Q, He H, Sun N, Zhang R, Yang CQ, Zhao LB. Population pharmacokinetics of ruxolitinib in children with hemophagocytic lymphohistiocytosis: focus on the drug-drug interactions. Cancer Chemother Pharmacol. 2023 Feb;91(2):121-132. doi: 10.1007/s00280-022-04494-4. Epub 2022 Dec 13. PMID: 36510033.

Jia MZ, Li WJ, Wang CJ, Zhang Q, Gao C, Huang XT, Zhu T, Zhang RD, Cui L, Li ZG. Tracing back of relapse clones by Ig/TCR gene rearrangements reveals complex patterns of recurrence in pediatric acute lymphoblastic leukemia. Int J Lab Hematol. 2023 Oct;45(5):717-725. doi: 10.1111/ijlh.14100. Epub 2023 May 17. PMID: 37194559.

Wei A, Zhang L, Ma H, Cui L, Zhang Q, Wang D, Chen S, Du J, Zhao X, Wang T, Zhang R, Zheng H, Li Z. Clinical Significance of Plasma Soluble MICB in Children With EBV-associated Hemophagocytic Lymphohistiocytosis. J Pediatr Hematol Oncol. 2023 May 1;45(4):e446-e454. doi: 10.1097/MPH.0000000000002652. Epub 2023 Mar 3. PMID: 36898046.

Jin FF, Wang CJ, Cui L, Liu FF, Wang KL, Li WJ, Li ZG. Interaction of E2F3a and CASP8AP2 Regulates Histone Expression and Chemosensitivity of Leukemic Cells. J Pediatr Hematol Oncol. 2023 Apr 1;45(3):e339-e344. doi: 10.1097/MPH.0000000000002558. Epub 2022 Sep 22. PMID: 36162009; PMCID: PMC10030168.

黄筱彤,李志刚,崔蕾. p27Kip1的生物学功能及其在肿瘤中作用的研究进展[J]. 中国小儿血液与肿瘤杂志,2023,28(5):329-333.

Gao H, Xu H, Wang C, Cui L, Huang X, Li W, Yue Z, Tian S, Zhao X, Xue T, Xing T, Li J, Wang Y, Zhang R, Li Z, Wang T. Optical Genome Mapping for Comprehensive Assessment of Chromosomal Aberrations and Discovery of New Fusion Genes in Pediatric B-Acute Lymphoblastic Leukemia. Cancers (Basel). 2022 Dec 21;15(1):35. doi: 10.3390/cancers15010035. PMID: 36612032; PMCID: PMC9817688.

Zhang Q, Zhao YZ, Ma HH, Wang D, Cui L, Li WJ, Wei A, Wang CJ, Wang TY, Li ZG, Zhang R. A study of ruxolitinib response-based stratified treatment for pediatric hemophagocytic lymphohistiocytosis. Blood. 2022 Jun 16;139(24):3493-3504. doi: 10.1182/blood.2021014860. PMID: 35344583.

Bi X, Zhang Q, Chen L, Liu D, Li Y, Zhao X, Zhang Y, Zhang L, Liu J, Wu C, Li Z, Zhao Y, Ma H, Huang G, Liu X, Wang QF, Zhang R. NBAS, a gene involved in cytotoxic degranulation, is recurrently mutated in pediatric hemophagocytic lymphohistiocytosis. J Hematol Oncol. 2022 Jul 28;15(1):101. doi: 10.1186/s13045-022-01318-z. PMID: 35902954; PMCID: PMC9331571.

Huang K, Chen Z, Wu R. "A personalized limited sampling approach to better estimate terminal half-life of FVIII concentrates": Comment from Huang et al. J Thromb Haemost. 2022 Oct;20(10):2444-2445. doi: 10.1111/jth.15833. PMID: 36123571.

Huang K, Wang Y, Zhen Y, Li G, Wu X, Zhang N, Chen Z, Wu R. Inter-individual variability in pharmacokinetics and clinical features in pediatric patients with severe hemophilia A. Thromb Res. 2022 May;213:71-77. doi: 10.1016/j.thromres.2022.03.008. Epub 2022 Mar 12. PMID: 35305529.

Yao JF, Wang D, Ma HH, Lian HY, Zhang L, Wang TY, Li ZG, Jiang J, Cui L, Zhang R. Characteristics and Treatment Outcomes of Pediatric Langerhans Cell Histiocytosis with Thymic Involvement. J Pediatr. 2022 May;244:194-202.e5. doi: 10.1016/j.jpeds.2022.01.007. Epub 2022 Jan 19. PMID: 35065150.

Sun J, Li Z, Li G, Huang K, Ai D, Liu G, Yao W, Xie X, Gu H, Zhen Y, Chen Z, Wu R. Low-dose immune tolerance induction in children with severe hemophilia A with high-titer inhibitors: Type of factor 8 mutation and outcomes. Res Pract Thromb Haemost. 2022 Oct 26;6(7):e12824. doi: 10.1002/rth2.12824. PMID: 36313984; PMCID: PMC9606347.

Sun J, Li Z, Huang K, Ai D, Li G, Xie X, Gu H, Liu G, Zhen Y, Chen Z, Wu R. F8 gene mutation spectrum in severe hemophilia A with inhibitors: A large cohort data analysis from a single center in China. Res Pract Thromb Haemost. 2022 Jun 8;6(4):e12723. doi: 10.1002/rth2.12723. PMID: 35702590; PMCID: PMC9175357.

Huang K, Zhen Y, Li G, Wu X, Chen Z, Wu R. Enhanced pharmacokinetics and reduced bleeds in boys with hemophilia A after switching to Kovaltry from other standard half-life factor VIII concentrates. Res Pract Thromb Haemost. 2022 Mar 25;6(2):e12686. doi: 10.1002/rth2.12686. PMID: 35356665; PMCID: PMC8956787.

Yue ZX, Xing TY, Zhao W, Zhao Q, Wang XS, Su Y, Gao C, Liu SG, Ma XL. MYCN amplification plus 1p36 loss of heterozygosity predicts ultra high risk in bone marrow metastatic neuroblastoma. Cancer Med. 2022 Apr;11(8):1837-1849. doi: 10.1002/cam4.4583. Epub 2022 Feb 9. PMID: 35137546; PMCID: PMC9041068.

Wang D, Chen XH, Wei A, Zhou CJ, Zhang X, Ma HH, Lian HY, Zhang L, Zhang Q, Huang XT, Wang CJ, Yang Y, Liu W, Wang TY, Li ZG, Cui L, Zhang R. Clinical features and treatment outcomes of pediatric Langerhans cell histiocytosis with macrophage activation syndrome-hemophagocytic lymphohistiocytosis. Orphanet J Rare Dis. 2022 Apr 4;17(1):151. doi: 10.1186/s13023-022-02276-y. PMID: 35379272; PMCID: PMC8981711.

Huang K, Ai D, Li G, Zhen Y, Wang Y, Zhang N, Huo A, Liu G, Chen Z, Wu R. Individualised prophylaxis based on personalised target trough FVIII level optimised clinical outcomes in paediatric patients with severe haemophilia A. Haemophilia. 2022 Nov;28(6):e209-e218. doi: 10.1111/hae.14635. Epub 2022 Jul 18. PMID: 35850182; PMCID: PMC9796890.

Zhao XX, Lian HY, Zhang L, Ma HH, Wang D, Zhao YZ, Liu W, Chen XH, Wang TY, Li ZG, Zhang R. Significance of serum Th1/Th2 cytokine levels in underlying disease classification of childhood HLH. Cytokine. 2022 Jan;149:155729. doi: 10.1016/j.cyto.2021.155729. Epub 2021 Oct 19. PMID: 34673333.

Yang Y, Wang C, Wang D, Cui L, Li N, Lian H, Ma H, Zhao Y, Zhang L, Liu W, Wang Y, Wu W, Zhang R, Li Z, Wang T. Clinical study of MAP2K1-mutated Langerhans cell histiocytosis in children. J Cancer Res Clin Oncol. 2022 Sep;148(9):2517-2527. doi: 10.1007/s00432-021-03810-4. Epub 2021 Sep 30. PMID: 34595543.

Lian H, Cui L, Yang Y, Wei A, Cheng H, Li N, Zhang L, Ma H, Zhao X, Wang T, Li Z, Zhang R. Second-line regimen for CNS-involved pediatric Langerhans cell histiocytosis. Pituitary. 2022 Feb;25(1):108-115. doi: 10.1007/s11102-021-01176-x. Epub 2021 Jul 24. PMID: 34302575.

Liu G, Huang K, Li G, Zhen Y, Li Z, Chen Z, Wu R. Real-world experience of emicizumab prophylaxis in young children with hemophilia A: retrospective data from China. Front Pediatr. 2022 Oct 19;10:992267. doi: 10.3389/fped.2022.992267. PMID: 36340724; PMCID: PMC9627604.

Gu H, Chen Z, Ma J, Ma J, Fu L, Zhang R, Wang T, Wu R. Case report: Effectiveness of sirolimus in a de novo FAS mutation leading to autoimmune lymphoproliferative syndrome-FAS and elevated DNT/Treg ratio. Front Pediatr. 2022 Jul 28;10:868193. doi: 10.3389/fped.2022.868193. PMID: 35967554; PMCID: PMC9366043.

Ai D, Huang K, Li G, Zhen Y, Wu X, Zhang N, Huo A, Chen Z, Wu R. Exploration of the minimum necessary FVIII level at different physical activity levels in pediatric patients with hemophilia A. Front Pediatr. 2022 Nov 1;10:1045070. doi: 10.3389/fped.2022.1045070. PMID: 36389359; PMCID: PMC9665406.

Yuan Y, Li J, Xue TL, Hu HR, Lin W, Liu SG, Zhang RD, Zheng HY, Gao C. Prognostic significance of NOTCH1/FBXW7 mutations in pediatric T cell acute lymphoblastic leukemia: a study of minimal residual disease risk-directed CCLG-ALL 2008 treatment protocol. Leuk Lymphoma. 2022 Jul;63(7):1624-1633. doi: 10.1080/10428194.2022.2032033. Epub 2022 Feb 6. PMID: 35129045.

Yang FF, Xue TL, Gao C, Wu Y, Lin W, Li J, Zhang RD, Zheng HY, Liu SG. Effects of SLCO1B1 on elimination and toxicities of high-dose methotrexate in pediatric acute lymphoblastic leukemia. Pharmacogenomics. 2022 Oct;23(15):821-834. doi: 10.2217/pgs-2022-0098. Epub 2022 Oct 4. PMID: 36193736.

Wang CJ, Jia MZ, Deng LP, Li WJ, Zhang Q, Zhang TJ, Li SY, Cui L, Li ZG. Interaction between CASP8AP2 and ZEB2-CtBP2 Regulates the Expression of LEF1. Pediatr Hematol Oncol. 2022 Sep;39(6):549-560. doi: 10.1080/08880018.2022.2033369. Epub 2022 Feb 10. PMID: 35139734.

Fan H, Xing T, Hong H, Duan C, Zhao W, Zhao Q, Wang X, Huang C, Zhu S, Jin M, Su Y, Gao C, Ma X. The expression of PHOX2B in bone marrow and peripheral blood predicts adverse clinical outcome in non-high-risk neuroblastoma. Pediatr Hematol Oncol. 2022 May;39(4):343-356. doi: 10.1080/08880018.2021.1995090. Epub 2021 Nov 9. PMID: 34752187.

刘潇,李志刚,王凯玲,. E2F3a功能域缺失对细胞柔红霉素敏感性的影响[J]. 北京医学,2022,44(1):54-57,63.


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